Discontinued programs run from first public evidence to last public news, active programs from first public evidence to today. Stage = furthest stage reached (discontinued) or current stage (active). Click a name for details, a reason or marker for its source.
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Legend for discontinued programs
Reason for discontinuation:EfficacySafetyStrategicNot disclosed
Line:Program activityLater news after discontinuation
Markers:MilestoneDiscontinuation announcedCorporate eventCorporate event after last ADPKD news
Active programs:First public evidence, then active to today
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Small molecule
Oligonucleotide
Gene therapy / editing
Antibody / biologic
Undisclosed
Repurposing
Active
Possibly inactive
Discontinued
Click a program for details
← Scroll to see all stages →
| Modality | Preclinical | IND | Phase 1 | Phase 2 | Phase 3+ | Approved |
|---|---|---|---|---|---|---|
| mRNA-upregulating small molecules |
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| mRNA-upregulating ASOs |
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| PKD protein correctors |
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| Signaling modulators |
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| Read-through correctors |
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| Gene therapy | ||||||
| Gene editing | ||||||
| Antibody / biologic |
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| Undisclosed | ||||||
| Repurposing |